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Research Associate III Molecular Biology - (Job Code RASR2016)

RA Pharmaceuticals seeks a full time Research Associate III - Molecular Biology at our offices located at 87 Cambridge Park Drive, Cambridge, MA 02140 to perform the following duties:

  • Develop new chemical methods for bio-conjugation and cyclization of peptides (15%);
  • Protein engineering and directed evolution of translation machinery using site directed mutagenesis, mRNA display and in vitro amino-acylation techniques, for in vitro translation of non-natural peptides (15%);
  • Proteomics analysis of ligand-protein interaction using various methods including gel, thermal stability and mass spectrometry analysis (10%);
  • Develop methods to screen and select for functionally active peptides using mRNA display (10%);
  • Prepare DNA samples using qPCR, PicoGreen assay and perform deep-sequencing runs on Illumina MiSeq instrument. Analyze processed sequencing data on Microsoft Excel for basic level analysis (20%);
  • Screening and testing in vitro translation of non-natural amino acids (20%); and
  • Purification and characterization of proteins using SDS-PAGE, affinity column chromatography like Ni-NTA purification or Protein-A affinity chromatography and size exclusion chromatography (10%).

Minimum Education and Experience Requirements: Master's degree, or foreign equivalent, in Biotechnology, Molecular Biology, Cell Biology, or closely related field.

Special Requirements: Knowledge, which may be gained through coursework or experience, to include each of the following: TA cloning; qPCR; PicoGreen assay; site directed mutagenesis; mRNA display; protein biotinylation; Mass spectrometry; affinity purification; Size exclusion chromatography; FPLC and DSF thermal stability assay.

Send resume to: info at rapharma dot com

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Scientist, Computational Chemistry - (Job Code CB2016)

Description: We are seeking an experienced and highly talented computational chemist to play a key role in the design and development of Ra’s innovative macrocyclic peptide and small molecule therapeutics. The successful candidate’s primary responsibility will be to develop robust models for ligand binding based on structural, SAR, and conformational analyses. They will then work closely with Ra’s synthetic chemistry, assay development, and pre-clinical development teams to help guide the design of molecules with improved in vivo PK/PD profiles.

Qualifications: Candidates must have a PhD in computational chemistry or a related discipline and at least 2 years of experience supporting drug discovery projects. In addition, candidates must meet the following criteria:

  • Deep expertise in ligand-receptor structural analysis and structure-based drug design
  • Deep expertise in molecular dynamics simulations and conformational analysis
  • Strong foundational understanding of molecular recognition
  • Experience performing virtual screens
  • Ability to program and analyze data in Python, R or another language
  • Ability to prepare clear visualizations of modeling results and present them effectively

The ideal candidate will also meet the following criteria:

  • Experience modeling peptides and macrocycles
  • Experience with the CCG Molecular Operating Environment or similar computation chemistry software
  • Experience with QSAR analysis and machine learning
  • Basic experience with synthetic organic chemistry
  • Experience developing therapeutics for the complement system

Title and salary commensurate with experience. To apply, please send your résumé and cover letter to hr at rapharma dot com.

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Director, Clinical Operations - (Job Code DCO2016)

Description: Ra Pharma is seeking an experienced and energetic person to lead our growing clinical operations department, reporting to the Chief Medical Officer. The Director of Clinical Operations will be responsible for all aspects of clinical operations including clinical trial startup, vendor selection and management , enrollment, study conduct, adherence to protocols, and study completion. The Director of Clinical Operations will also play a key role in the development of study budgets in close collaboration with Senior Management.

Responsibilities: Ensure clinical trial programs are properly resourced, managed and executed within budget and in accordance with established timelines and quality standards. Prepare protocols, amendments, case report forms, informed consent forms, and other documentation required for conduct of a clinical trial. Maintain and manage clinical trial files and documents. Prepare regulatory documents, such as annual reports, IB updates, and final clinical study reports for assigned protocols. Manage day-to-day clinical operations, including management of vendors and subcontractors (e.g., CRO). Participate in investigator meetings. Coordinate and plan for the availability of clinical and non-clinical supplies necessary to meet study requirements. Travel to sites when necessary.

Qualifications: The Director, Clinical Operations should have a minimum of 8 years of experience in the pharmaceutical industry, with minimum 5 years direct experience in planning and managing clinical trials. The candidate must have solid understanding of pharmaceutical clinical development processes and have experience with clinical monitoring. The candidate should have significant experience with responsible roles in the conduct or management of Phase I, II and III clinical trials. Experience in rare diseases is highly desirable. The candidate must have a BA/BS degree or equivalent; health science degree or biologic science degree is preferred. The candidate must have a good working knowledge of medical terminology, physiology and pharmacology and an excellent knowledge of applicable U.S. and international regulations and guidelines. Excellent oral and written communication, organizational and planning skills are required, with a proven ability to manage budgets. The candidate should be detail-oriented, a self-starter and be comfortable with broad responsibilities in an entrepreneurial, fast-paced, small company environment.

To apply, please send your résumé and cover letter to hr at rapharma dot com.

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Clinical Trial Manager - (Job Code CTM2016)

The Clinical Trial Manager will manage all clinical study activities under his/her responsibility. The individual will manage the strategic and operational elements of study conduct in conjunction with relevant functional lines.

Responsibilities:
The primary responsibility will be the successful execution of clinical studies from study planning to closeout. Deliver projects on time, within budget and in compliance to all applicable regulations.

Manage study conduct, ensure operating procedures and company policies are followed and trials meet all applicable regulations and guidelines required. This individual will be responsible for the oversight of the CRO and other vendors, oversight of contracts, timelines and budgets, for studies done in and outside US.

Accountability for the preparation and finalization of key clinical documents, which include the clinical protocol, informed consent, case report form and other essential study documents.

Ensure deliverables are carried out according to the study plan. Ensure enrollment commitments meet the projected enrollment across the regions at the clinical study level, monitor patient recruitment at the global level, and ensure timely and accurate documentation and communication of study progress and issue escalation.

Exhibit proficiency and act as a Subject Operations Expert in clinical trials involving complex design issues. Will provide solutions and guidance as needed.

Will interface and collaborate with investigators, IRBs/ECs, contractors/vendors and company personnel as required.

Qualifications

  • A minimum of a Bachelor’s Degree (advanced degree preferred) with at least 5 years of clinical operations or related experience required.
  • Requires clinical operations and GCP/ICH knowledge.
  • Requires strong communication (both oral and written), organizational and interpersonal skills. Ability to foster team productivity and cohesiveness is preferred.
  • Requires experience managing a CRO and vendors.
  • Requires experience in global studies with flexibility and able to manage global or regional teams in a virtual environment.
  • Computer skills and experience with some project management software and tools.
  • Ability to travel (domestic and international).

To apply, please send your résumé and cover letter to hr at rapharma dot com.

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Research Associate– Target Biology - (Job Code 2016RATB)

Description: We are currently seeking a Research Associate with experience in drug discovery to join our Target Biology group. Primary responsibilities will include the execution of established biochemical and cell-based assays for the characterization of drug candidates. Additional responsibilities will include assay development and general laboratory support.

Qualifications: Candidates must have a B. in cell biology, molecular biology, biochemistry, or a related discipline with experience in a drug discovery setting. The successful candidate will be a flexible and careful bench scientist who is eager to learn and excited by the challenges and rewards of working in a highly demanding start-up environment.

(Title and compensation will be commensurate with qualifications and experience.)

To apply, please send your résumé and cover letter to hr at rapharma dot com.

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Compliance Specialist, Quality Assurance - (Job Code 2016QA)

Description: We are seeking an experienced GMP compliance specialist to review and manage the compliance aspects of manufacturing documentation and to establish and maintain Quality systems and procedures. In particular, the Compliance Specialist will work internally with the Pharmaceutical Development group and externally with manufacturing vendors to ensure regulations and procedures are established, followed and documented as appropriate to the phase of development and adapted through drug development.

Qualifications: Candidates must have a minimum BS degree in biochemistry, chemistry, or a related discipline with 5 years of GMP regulated industry experience. Candidates must have a demonstrable track record of increasing responsibility in knowledge and application of GMPs to create and maintain compliant processes to match Ra Pharma’s manufacturing model.

Candidates should have:

  • hands-on working experience in either manufacturing or QC testing lab
  • knowledge of current Good Manufacturing Practices for product manufacture, filling and testing
  • knowledge of international guidances (EMA, ICH) and their application
  • management and interface skills with external vendors and QA
  • ability to work in team environment
  • highly organized, self-starter

Please send cover letter and resume to hr at rapharma dot com.

Salary and title commensurate with experience.

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Scientist-Target Biology - (Job Code TBS2016)

Description: We are currently seeking a Scientist with expertise in the innate immune system to join our Target Biology group. Primary responsibilities will include the design, development, and execution of biochemical and cell-based assays for the validation of therapeutic targets and characterization of drug candidates. Additional responsibilities will include developing expertise in biology of targets and disease areas of interest and using this knowledge to advance projects as a member of a project team.

Qualifications: Candidates must have a Ph.D. in cell biology, molecular biology, biochemistry, or a related discipline with demonstrated scientific expertise in the biology of the innate immune system. The successful candidate will be a flexible and careful scientist with leadership potential who is eager to learn and excited by the challenges and rewards of working in a highly demanding start-up environment.

(Title and compensation will be commensurate with qualifications and experience.)

To apply, please send your résumé and cover letter to hr at rapharma dot com.

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Ra Pharma™ is building a dynamic team of scientists to solve the most difficult problems in drug discovery today. We seek highly motivated individuals who enjoy working in a collaborative atmosphere and a goal-oriented environment.

Ra Pharma™ is an equal opportunity employer offering competitive cash and stock compensation, excellent employee benefits and the opportunity for personal and professional growth in an outstanding and intellectually challenging work environment.