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Scientist, Computational Chemistry - (Job Code CB2016)

Description: We are seeking an experienced and highly talented computational chemist to play a key role in the design and development of Ra’s innovative macrocyclic peptide and small molecule therapeutics. The successful candidate’s primary responsibility will be to develop robust models for ligand binding based on structural, SAR, and conformational analyses. They will then work closely with Ra’s synthetic chemistry, assay development, and pre-clinical development teams to help guide the design of molecules with improved in vivo PK/PD profiles.

Qualifications: Candidates must have a PhD in computational chemistry or a related discipline and at least 2 years of experience supporting drug discovery projects. In addition, candidates must meet the following criteria:

  • Deep expertise in ligand-receptor structural analysis and structure-based drug design
  • Deep expertise in molecular dynamics simulations and conformational analysis
  • Strong foundational understanding of molecular recognition
  • Experience performing virtual screens
  • Ability to program and analyze data in Python, R or another language
  • Ability to prepare clear visualizations of modeling results and present them effectively

The ideal candidate will also meet the following criteria:

  • Experience modeling peptides and macrocycles
  • Experience with the CCG Molecular Operating Environment or similar computation chemistry software
  • Experience with QSAR analysis and machine learning
  • Basic experience with synthetic organic chemistry
  • Experience developing therapeutics for the complement system

Title and salary commensurate with experience. To apply, please send your résumé and cover letter to hr at rapharma dot com.

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Clinical Trial Manager - (Job Code CTM2016)

The Clinical Trial Manager will manage all clinical study activities under his/her responsibility. The individual will manage the strategic and operational elements of study conduct in conjunction with relevant functional lines.

The primary responsibility will be the successful execution of clinical studies from study planning to closeout. Deliver projects on time, within budget and in compliance to all applicable regulations.

Manage study conduct, ensure operating procedures and company policies are followed and trials meet all applicable regulations and guidelines required. This individual will be responsible for the oversight of the CRO and other vendors, oversight of contracts, timelines and budgets, for studies done in and outside US.

Accountability for the preparation and finalization of key clinical documents, which include the clinical protocol, informed consent, case report form and other essential study documents.

Ensure deliverables are carried out according to the study plan. Ensure enrollment commitments meet the projected enrollment across the regions at the clinical study level, monitor patient recruitment at the global level, and ensure timely and accurate documentation and communication of study progress and issue escalation.

Exhibit proficiency and act as a Subject Operations Expert in clinical trials involving complex design issues. Will provide solutions and guidance as needed.

Will interface and collaborate with investigators, IRBs/ECs, contractors/vendors and company personnel as required.


  • A minimum of a Bachelor’s Degree (advanced degree preferred) with at least 5 years of clinical operations or related experience required.
  • Requires clinical operations and GCP/ICH knowledge.
  • Requires strong communication (both oral and written), organizational and interpersonal skills. Ability to foster team productivity and cohesiveness is preferred.
  • Requires experience managing a CRO and vendors.
  • Requires experience in global studies with flexibility and able to manage global or regional teams in a virtual environment.
  • Computer skills and experience with some project management software and tools.
  • Ability to travel (domestic and international).

To apply, please send your résumé and cover letter to hr at rapharma dot com.

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Compliance Specialist, Quality Assurance - (Job Code 2016QA)

Description: We are seeking an experienced GMP compliance specialist to review and manage the compliance aspects of manufacturing documentation and to establish and maintain Quality systems and procedures. In particular, the Compliance Specialist will work internally with the Pharmaceutical Development group and externally with manufacturing vendors to ensure regulations and procedures are established, followed and documented as appropriate to the phase of development and adapted through drug development.

Qualifications: Candidates must have a minimum BS degree in biochemistry, chemistry, or a related discipline with 5 years of GMP regulated industry experience. Candidates must have a demonstrable track record of increasing responsibility in knowledge and application of GMPs to create and maintain compliant processes to match Ra Pharma’s manufacturing model.

Candidates should have:

  • hands-on working experience in either manufacturing or QC testing lab
  • knowledge of current Good Manufacturing Practices for product manufacture, filling and testing
  • knowledge of international guidances (EMA, ICH) and their application
  • management and interface skills with external vendors and QA
  • ability to work in team environment
  • highly organized, self-starter

Please send cover letter and resume to hr at rapharma dot com.

Salary and title commensurate with experience.

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Scientist-Target Biology - (Job Code TBS2016)

Description: We are currently seeking a Scientist with expertise in the innate immune system to join our Target Biology group. Primary responsibilities will include the design, development, and execution of biochemical and cell-based assays for the validation of therapeutic targets and characterization of drug candidates. Additional responsibilities will include developing expertise in biology of targets and disease areas of interest and using this knowledge to advance projects as a member of a project team.

Qualifications: Candidates must have a Ph.D. in cell biology, molecular biology, biochemistry, or a related discipline with demonstrated scientific expertise in the biology of the innate immune system. The successful candidate will be a flexible and careful scientist with leadership potential who is eager to learn and excited by the challenges and rewards of working in a highly demanding start-up environment.

(Title and compensation will be commensurate with qualifications and experience.)

To apply, please send your résumé and cover letter to hr at rapharma dot com.

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Ra Pharma™ is building a dynamic team of scientists to solve the most difficult problems in drug discovery today. We seek highly motivated individuals who enjoy working in a collaborative atmosphere and a goal-oriented environment.

Ra Pharma™ is an equal opportunity employer offering competitive cash and stock compensation, excellent employee benefits and the opportunity for personal and professional growth in an outstanding and intellectually challenging work environment.